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刊物期号: 201901

参茸酒的食用安全性研究(141)

作者: 郭 艳,蒋中仁,彭 蔷,刘科亮

地址:四川省疾病预防控制中心,四川 成都 邮编:610000
摘要 通过动物试验评价参茸酒的食用安全性。依据《保健食品检验与评价技术规范》(2003年版)相关方法对参茸酒进行大、小鼠急性经口毒性试验、3项遗传毒性试验(Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验)、大鼠30 d喂养试验。试验结果显示,大鼠、小鼠急性经口MTD值>15000 mg/kg·BW,属无毒级;3项遗传毒性试验未见参茸酒致突变作用;30 d喂养试验,3个剂量组雌、雄大鼠的每周体重、每周进食量、每周食物利用率、总食物利用率、脏体比值、血液学指标和末期血生化指标与15 %vol基酒对照组比较,雌鼠中剂量组单核细胞、雄鼠3个剂量组总蛋白显著升高(P<0.01,P<0.01,P<0.01,P<0.05),其他指标均无显著性差异(P>0.05);除大鼠自发病变外未引起脏器组织中毒性损伤。参茸酒在本试验条件下未显示有急性毒性、遗传毒性或亚急性毒性。
关键词 马鹿茸; 人参; 保健酒; 安全性
中图分类号: TS262.91;TS261.7;TS201.6 文献标识码: A 文章编号: 1001-9286(2019)01-0141-06

英文标题: Edible Safety of Ginseng-Antler Liquor

英文作者: GUO Yan, JIANG Zhongren, PENG Qiang and LIU Keliang

英文地址: Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan 610000, China

英文摘要 The edible safety of ginseng-antler liquor was assessed by animal test. The acute oral toxicity test of mice and rats, genetic toxicity tests (including mice bone marrow cell micronucleus test, mice sperm abnormality test and Ames test) and 30-day feeding test on rats were carried out in accordance with “Technical Standards for Testing & Assessment of Health Food (2003)”. The results showed that, MTD for mice and rats was more than 15000 mg/kg·BW, indicating to non-toxic grade; the negative results were obtained in genetic toxicity tests; in 30-day feeding test, there was no significant difference in weight increase, food intake, food utilization, organ coefficient, blood routine examination or blood biochemistry index between treatment group and 15 %vol base liquor control group (P>0.05), except the significant increase in monocyte of middle-dose female rats and in total protein of 3 male rats treatment groups (P<0.01, P<0.01, P<0.01, P<0.05); some of the rats had pathologic changes but no toxic injury on organs was found. Accordingly, ginseng-antler liquor presented no acute toxicity, no genetic toxicity and no subchronic toxicity in the test.
英文关键词 wapiti velvet antler; ginseng; healthcare liquor; safety
      

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