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刊物期号: 201710

高效液相色谱-串联质谱检测酒类产品中11种PDE-5抑制剂及其衍生剂(126)

作者: 翟纹静1,2

地址:1. 苏州出入境检验检疫综合技术中心,江苏 苏州 215100; 2. 苏州世标检测技术有限公司,江苏 苏州 215100
摘要 建立了高效液相色谱串联质谱仪对酒类产品中11 种PDE-5抑制剂及其衍生剂的快速分析方法。样品经乙腈∶水(1∶1,v/v)超声提取,Atlantis d C18色谱柱(2.1×150 mm,3 μm)为分析柱,0.1 %甲酸溶液和0.1 %甲酸乙腈为流动相,电喷雾正离子多反应监测模式进行检测,外标法定量。试验结果表明,该方法的RSD 值范围为0.57 %~11.69 %,回收率范围在60.0 %~118.6 %,该方法的线性相关性良好,检测低限、精密度和准确度均符合要求,能够满足酒类产品中11种PDE-5抑制剂及其衍生剂的检测要求。
关键词 液质联用仪; 酒类; PDE-5抑制剂
中图分类号: TS262.7;TS261.7;TS261.4 文献标识码: A 文章编号: 1001-9286(2017)10-0126-04

英文标题: Determination of 11 Kinds of PDE-5 Inhibitors and their Derivatives in Alcoholic Drinks by LC-MS/MS

英文作者: ZHAI Wenjing1,2

英文地址: 1. Suzhou Entry-Exit Inspection and Quarantine Bureau, Suzhou, Jiangsu 215100; 2.Suzhou World Standard Testing Technology Co. Ltd., Suzhou, Jiangsu 215100, China

英文摘要 A method of high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) had been developed for the determination of 11 kinds of PDE-5 inhibitors and their derivatives in alcoholic drinks. Samples were diluted with acetonitrile∶water (1∶1, v:v) and the analyte was separated by an Atlantis dC18 column (2.1×150 mm, 3 μm)using a mobile phase consisting of 0.1 % formic acid and acetonitrile with 0.1 % formic acid. The analyte was detected in multiple-reaction monitoring (MRM) mode via positive electrospray ionization (ESI+). The determination results showed that the RSD was between 0.57 % to 11.69 % and the recovery was between 60.0 % to 118.6 % at three spiked levels. The method was characterized by its excellent purification effect, high sensitivity and good accuracy, and it could be used for the determination of 11 kinds of PDE-5 inhibitors and their derivatives in alcoholic drinks.
英文关键词 high performance liquid chromatography tandem mass spectrometry (LC-MS/MS); alcoholic drinks; PDE-5 inhibitor
      

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